What's new? This blog keeps you up-to-date with the latest news, events and campaigns at OLS.

We combine xCELLigence assays with NovoCyte ?ow cytometric analyses to characterize two key immunological prophylactic mechanisms. First, we track Bispeci?c T Cell Engager (BiTE)-mediated stimulation of cancer cell killing by T cells. Next, we shift our focus to NETosis, a cell death process that occurs when stimulated neutrophils cast an extracellular web containing DNA, histones, and anti-bacterial proteins that ensnare/neutralize invading organisms.

 

CASY’s capabilities for accurate cell counting, and importantly for straightforward cell volume and aggregate measurement supports standardization of hemocompatibility experiments.

 

+ xCELLigence Protocols, Tips & Tricks +
Evaluating Drug-Mediated Cytotoxicity in Real Time

 

3 new application notes describe the use of NovoCyte for HPV mRNA expression analysis, real-time Ca 2+ measurement at the single cell level and the accurate CD34+ cells enumeration in hematopoirtic transplantation.

 

In this webinar, viewers will have the chance to learn about tools and recent developments in flow cytometry that simplify assay design and workflow.

 

Join us for this free Seminar Tuesday, May 09 2017, 12:15 - 14:00 and learn more about cell assays for evaluation of cell killing, immune cell activation, infection kinetics, cytopathogenicity, cytotoxicity, receptor-interaction, cell-cell interaction and cell migration/invasion.

 

How Cancer Drug Doxorubicin induces Cardiotoxicity

A recent nature paper provides new insights how the anticancer agent Doxorubicin induces cytotoxicity in human induced pluripotent stem cells-derived cardiomyocytes (iPS-CMs).

 

The destruction of Daudi B cells by T cells in the presence or absence of a Bispecific T Cell Engager (BiTE) was analyzed in real-time using the xCELLigence technology. Concurrently, because cells are not destroyed by this technique, it was possible to remove samples at select time points and confirm cell killing by flow cytometry. Moreover, by removing media from select wells of the xCELLigence microtiter plate, the secretion of 7 different cytokines and 6 different effector molecules were also analyzed using a bead-based multiplex assay combined with flow cytometry.

 

The publication of over 1250 peer-reviewed scientific papers citing the xCELLigence technology is a testament to the integration of the xCELLigence system as part of routine cell analysis and drug discovery workflow.

 

Join ACEA's global flow cytometry webinar featuring renowned speakers, namely Paul Wallace (Roswell Park Cancer Institute, President of CYTO), Bill Telford (NIH/NCI), and Chris Groves (MedImmune) and learn the latest instrumentation and application news related to flow cytometry.

 

Measurement of HER2 signaling activity, rather than absolute HER2 levels, may more accurately diagnose HER2-driven breast cancer. A new diagnostic test, the CELx HER2 Signaling Profile (CELx HSP) test, is demonstrated to measure real-time HER2 signaling function in live primary cells.

 

SIZE MATTERS. big show for small particles.

Join us for a free Flow Cytometry and Microparticles workshop
Thursday Jan. 12, 2017 | 10:00 – 16:00 | Forschungszentrum Borstel, Reflektorium, Parkallee 1-40, 23845 Borstel

 
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