How Cancer Drug Doxorubicin induces Cardiotoxicity

Doxorubicin is a highly effective anticancer agent but causes cardiotoxicity in many patients. The mechanisms of doxorubicin-induced cardiotoxicity remain incompletely understood. In a recent Nature Scientific Report, Liqun Zhao and Baolin Zhang from the U.S. Food and Drug Administration provided compelling evidence that doxorubicin-induced upregulation of death receptors in cardiomyocytes leads to spontaneous apoptosis which is exacerbated by physiologically relevant concentrations of death ligands such as TRAIL. 

The complete publication can be viewed here.  

Figure: A working model by which doxorubicin induces cardiotoxicity through upregulation of death receptors mediated apoptosis in cardiomyocyte by Springer Nature under CC-BY-4.0




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