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ACEA’s xCELLigence Research Grant is aimed at helping scientists achieve their research goals by
providing them free access to Real-Time Cell Analysis (RTCA) technology. The winning scientist receives an xCELLigence instrument, consumables, and consultation for up to 6 months.

 

We combine xCELLigence assays with NovoCyte ?ow cytometric analyses to characterize two key immunological prophylactic mechanisms. First, we track Bispeci?c T Cell Engager (BiTE)-mediated stimulation of cancer cell killing by T cells. Next, we shift our focus to NETosis, a cell death process that occurs when stimulated neutrophils cast an extracellular web containing DNA, histones, and anti-bacterial proteins that ensnare/neutralize invading organisms.

 

CASY’s capabilities for accurate cell counting, and importantly for straightforward cell volume and aggregate measurement supports standardization of hemocompatibility experiments.

 

+ xCELLigence Protocols, Tips & Tricks +
Evaluating Drug-Mediated Cytotoxicity in Real Time

 

3 new application notes describe the use of NovoCyte for HPV mRNA expression analysis, real-time Ca 2+ measurement at the single cell level and the accurate CD34+ cells enumeration in hematopoirtic transplantation.

 

How Cancer Drug Doxorubicin induces Cardiotoxicity

A recent nature paper provides new insights how the anticancer agent Doxorubicin induces cytotoxicity in human induced pluripotent stem cells-derived cardiomyocytes (iPS-CMs).

 

The destruction of Daudi B cells by T cells in the presence or absence of a Bispecific T Cell Engager (BiTE) was analyzed in real-time using the xCELLigence technology. Concurrently, because cells are not destroyed by this technique, it was possible to remove samples at select time points and confirm cell killing by flow cytometry. Moreover, by removing media from select wells of the xCELLigence microtiter plate, the secretion of 7 different cytokines and 6 different effector molecules were also analyzed using a bead-based multiplex assay combined with flow cytometry.

 

The publication of over 1250 peer-reviewed scientific papers citing the xCELLigence technology is a testament to the integration of the xCELLigence system as part of routine cell analysis and drug discovery workflow.

 

Measurement of HER2 signaling activity, rather than absolute HER2 levels, may more accurately diagnose HER2-driven breast cancer. A new diagnostic test, the CELx HER2 Signaling Profile (CELx HSP) test, is demonstrated to measure real-time HER2 signaling function in live primary cells.

 

Webinar NovoCyte Flow Cytometry

November 17: We will present the importance of studying free radicals, their dual roles as both toxic and beneficial compounds in cellular response and immune function. We will also introduce a new panel of multicolor CytoTell™ cell proliferation and tracking dyes that are well excited by major NovoCyte laser lines.

 

xCELLigence in Personalized Cancer Medicine

Read Open Access Article - Culture and Drug Profiling of Patient Derived Malignant Pleural Effusions for Personalized Cancer Medicine

 

For their ability to quantitatively monitor – in a label-free manner – cell number, morphology, and adhesion strength for a broad array of applications, ACEA’s line of real-time cell analyzers has been awarded top honors from Corporate Vision Magazine.

 
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