Cell Migration Assay: A new Publication examines kinetics of growth factors and inhibitors using xCELLigence

"Considering that growth factors or their inhibitors may exert maximal effects at different
time points after treatment, it is useful to monitor cell behaviour continuously and over a prolonged period of time. The precise determination of peak migratory/invasive activity of a given cell population may aid in deciphering the underlying mechanism of action of receptor kinases and their inhibitors."

Our data suggest that the clinical efficiency of dasatinib may in part be due to cross-inhibition of
tumour-promoting TGF-β signalling. Dasatinib may be useful as a dual TGF-β/SRC inhibitor in experimental and clinical therapeutics to prevent metastatic spread in late-stage PDAC and other tumours.

→ click here to access the article online.

Dasatinib blocks transcriptional and promigratory responses to transforming growth factor-beta in pancreatic adenocarcinoma cells through inhibition of Smad signalling: implications for in vivo mode of action

Tobias Bartscht, Benjamin Rosien, Dirk Rades, Roland Kaufmann, Harald Biersack, Hendrik Lehnert, Frank Gieseler and Hendrik Ungefroren

Molecular Cancer (2015) 14:199. DOI 10.1186/s12943-015-0468-0


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xCELLigence DP

Zell-Migrations Assays und Zellanalytik in Echtzeit xCELLigence DP: Dual Purpose System – klassische Zellanalytik oder markerfreie online Zellmigrations-/Zell-Invasions Assays (CIM) in Echtzeit: 3 Stationen für E-Plates oder CIM Plates (Boyden Chambers) mit je 16 wells. Individuelle Experimente für die Stationen konfigurierbar. Neben klassischen Experimenten zu Zell-Proliferation, Zytotoxizität, Adhäsion,...

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