Fibroblast-mediated Migration and Invasion Kinetics: Monitoring Co-culture Effect in Real-Time

New open access paper available: 

The local tumor microenvironment contributes to the transformed phenotype in cancer by providing specific environmental cues that alter the cells behavior and promotes metastasis. Dr. Patrick Kiely and his team at University of Limerick (Ireland) used xCELLigence technology to investigate how human fibroblasts alter cancer cell behavior. Dr. Kiely, in his latest publication demonstrated that co-culturing human dermal fibroblast enhanced the proliferation of colon cancer cells. This is also the 1st study that provides real-time data on fibroblast-mediated migration and invasion kinetics of colon cancer cells.

Dowling, C. M., Herranz Ors, C. and Kiely, P. A.  (2014)  Using real-time impedance-based assays to monitor the effects of fibroblast-derived media on the adhesion, proliferation, migration and invasion of colon cancer cells. Biosci. Rep. 34(4):art:e00126.doi:10.1042/BSR20140031

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E-Plate Inserts are single use, disposable devices used for performing cell-cell interaction assays on the RTCA DP, SP, MP or iCELLigence Instruments. The E-Plate Insert comprises a plate cover (lid), the insert device itself, and a lower receiver plate The insert device has 16 wells that are sealed at the bottom with a microporous polyethylene terephthalate (PET) membrane. The median pore size of the membrane is 0.4 µm. The receiver...

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