New Cell Migration Assay paper: Can Ionizing radiation induce motility in carcinoma cells?

Prof. Dr. Hendrik Ungefroren, University Hospital Schleswig-Holstein, Germany:

"In this study, we examined the effects of ionizing radiation (IR) on tumor cells from lung and pancreas as an in vitro correlate to radiotherapy of cancer patients. Using a xCELLigence DP real-time migration assay, which provided high-quality kinetic data, we were able to show that radiation treatment induces a strong increase in random cell motility that was mediated by IR-induced autocrine production of transforming growth factor (TGF)-beta. 

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→ click here to access the article online.

Ionizing radiation induces a motile phenotype in human carcinoma cells in vitro through hyperactivation of the TGF-beta signaling pathway; Cedric Carl, Anne Flindt, Julian Hartmann Markus Dahlke, Dirk Rades, Jürgen Dunst, Hendrik Lehnert, Frank Gieseler, Hendrik Ungefroren. Cell. Mol. Life Sci. August 2015; DOI 10.1007/s00018-015-2003-2

 
 

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xCELLigence DP

Zell-Migrations Assays und Zellanalytik in Echtzeit xCELLigence DP: Dual Purpose System – klassische Zellanalytik oder markerfreie online Zellmigrations-/Zell-Invasions Assays (CIM) in Echtzeit: 3 Stationen für E-Plates oder CIM Plates (Boyden Chambers) mit je 16 wells. Individuelle Experimente für die Stationen konfigurierbar. Neben klassischen Experimenten zu Zell-Proliferation, Zytotoxizität, Adhäsion,...

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