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CASY was used for evaluation of the cytotoxicity of anti-cancer drug combinations. Novel polychemotherapy regimens were defined using CASY Chemosensitivity Assays.

 

We combine xCELLigence assays with NovoCyte ?ow cytometric analyses to characterize two key immunological prophylactic mechanisms. First, we track Bispeci?c T Cell Engager (BiTE)-mediated stimulation of cancer cell killing by T cells. Next, we shift our focus to NETosis, a cell death process that occurs when stimulated neutrophils cast an extracellular web containing DNA, histones, and anti-bacterial proteins that ensnare/neutralize invading organisms.

 

+ xCELLigence Protocols, Tips & Tricks +
Evaluating Drug-Mediated Cytotoxicity in Real Time

 

Join us for this free Seminar Tuesday, May 09 2017, 12:15 - 14:00 and learn more about cell assays for evaluation of cell killing, immune cell activation, infection kinetics, cytopathogenicity, cytotoxicity, receptor-interaction, cell-cell interaction and cell migration/invasion.

 

How Cancer Drug Doxorubicin induces Cardiotoxicity

A recent nature paper provides new insights how the anticancer agent Doxorubicin induces cytotoxicity in human induced pluripotent stem cells-derived cardiomyocytes (iPS-CMs).

 

The destruction of Daudi B cells by T cells in the presence or absence of a Bispecific T Cell Engager (BiTE) was analyzed in real-time using the xCELLigence technology. Concurrently, because cells are not destroyed by this technique, it was possible to remove samples at select time points and confirm cell killing by flow cytometry. Moreover, by removing media from select wells of the xCELLigence microtiter plate, the secretion of 7 different cytokines and 6 different effector molecules were also analyzed using a bead-based multiplex assay combined with flow cytometry.

 

Killing Cancer Cells: Pictures start Moving

How to transform your Cytotoxicity Assays into a thriller: Look beyond the endpoint-assay. This article compares current technologies.

 

Join us: Monday, April 24 16:15 - 17:15
Smart Counting - cell viability and more in just seconds
Kinetics do the Trick - better understand cellular processes