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Virus infectious titer can be determined using real-time cell analysis (RTCA) + Impedance signal decrease after virus infection of Vero cells was dose-dependent. + RTCA is a reproducible and robust high-throughput virus titration method. + RTCA can be used in viral vaccine process development.

 

Continuously Screening Biofilms in Real Time

A new PLoS article describes monitoring of biofilm formation of Staphylococcus and Streptococcus strains using xCELLigence continuous impedance measurements - a technology opening new opportunities in the biofilm research arena for screening of strains and evaluation of bioactives and antimicrobials.

 

Using xCELLigence continuous impedance measurements, distinct phases of P. aeruginosa biofilm formation were revealed. Antibiotic effects were characterized with a precision superior to crystal violet staining.

 

A new publication describes really inspiring results: The authors report how they used xCELLigence cell assays to remove an ambiguity due to contradictory previous findings regarding PKC receptors - based on the instrument's ability of continuous long-term measurements with full-kinetics read-outs.

 

ACEA’s xCELLigence Research Grant is aimed at helping scientists achieve their research goals by
providing them free access to Real-Time Cell Analysis (RTCA) technology. The winning scientist receives an xCELLigence instrument, consumables, and consultation for up to 6 months.

 

We combine xCELLigence assays with NovoCyte ?ow cytometric analyses to characterize two key immunological prophylactic mechanisms. First, we track Bispeci?c T Cell Engager (BiTE)-mediated stimulation of cancer cell killing by T cells. Next, we shift our focus to NETosis, a cell death process that occurs when stimulated neutrophils cast an extracellular web containing DNA, histones, and anti-bacterial proteins that ensnare/neutralize invading organisms.

 

How Cancer Drug Doxorubicin induces Cardiotoxicity

A recent nature paper provides new insights how the anticancer agent Doxorubicin induces cytotoxicity in human induced pluripotent stem cells-derived cardiomyocytes (iPS-CMs).

 

The destruction of Daudi B cells by T cells in the presence or absence of a Bispecific T Cell Engager (BiTE) was analyzed in real-time using the xCELLigence technology. Concurrently, because cells are not destroyed by this technique, it was possible to remove samples at select time points and confirm cell killing by flow cytometry. Moreover, by removing media from select wells of the xCELLigence microtiter plate, the secretion of 7 different cytokines and 6 different effector molecules were also analyzed using a bead-based multiplex assay combined with flow cytometry.

 

The publication of over 1250 peer-reviewed scientific papers citing the xCELLigence technology is a testament to the integration of the xCELLigence system as part of routine cell analysis and drug discovery workflow.

 

Measurement of HER2 signaling activity, rather than absolute HER2 levels, may more accurately diagnose HER2-driven breast cancer. A new diagnostic test, the CELx HER2 Signaling Profile (CELx HSP) test, is demonstrated to measure real-time HER2 signaling function in live primary cells.

 

xCELLigence in Personalized Cancer Medicine

Read Open Access Article - Culture and Drug Profiling of Patient Derived Malignant Pleural Effusions for Personalized Cancer Medicine

 

For their ability to quantitatively monitor – in a label-free manner – cell number, morphology, and adhesion strength for a broad array of applications, ACEA’s line of real-time cell analyzers has been awarded top honors from Corporate Vision Magazine.

 
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