Stem cells – Spheroids – Organoids – Tissues
Think in new dimensions – CERO is overcoming known limitations of static cultures.
Easy, ready-to-use protocols, standardizable workflows and autoadhesion of cells without any need for Carriers or Matrigel are just a few of the advantages.
As a result, CERO enables high yield expansion of pluripotent stem cells or long term cultivation of tissue for >20 days (Spheroids >80 or Organoids >180).
Cultivating hepatocyte spheroids in CERO considerably improves expansion, differentiation, maturation and hepatic virus infection compared to monolayer culture. Our research takes advantage from healthy cells even from long-term cultures in CERO. Moreover, we are now able to perform 3D long-term culture of human tissue specimen in CERO - a paradigm shift.
Webinar | Webinar | 10 am
In this webinar you will get insights into our novel 3D Bioreactor and Incubator „CERO“ suitable for long-term culture of spheroids, organoids and tissues.Read more ›
Workshop | BioSysM & Biocenter, LMU Munich | 9 am
POSTPONED! At the Light Sheet Microscope Workshop, OLS is organizing Hands – on session for CERO – 3D Bioreactor and X-CLARITY – Tissue Clearing Systems. OLS will give short talks and present the technologies to the attendees. Additionally, OLS will provide samples (Spheroids) and Cleared tissues for Light Sheet Microscopy sessions.Read more ›
Generation of HepaRG Spheroids in the CERO
Scientific Poster: "Establishment and validation of the 3D cultivation system“CERO” for hepatic spheroids to study viral hepatitis", presented at the 2018 EMBL Symposium "Organoids: Modelling Organ Development and Disease in 3D Culture"
Expansion Protocol Pluripotent Stem Cells (iPSC and ESC)
Differentiation Protocol Organoids from Pluripotent Stem Cells
Instructions for setting system out of Operation, no use for > 4 weeks