Webinar
Modeling anti-tumor function of human T cells

Mouse models have been essential for establishing the role of the T cells in anti-tumor responses, but they have limited utility in translational studies for the testing of candidate therapeutics due to lack of cross-reactivity of many human antibodies to mouse receptors. Most of the human cell-based models for studying anti-tumor T cell responses, however, have significant biological or practical limitations that constrain their usefulness.