Cell Counter CASY

The cell counter & analyzer for cell research

Multi-Parameter - Accurate - Reproducible

Highlights - CASY cell counter & analyzer

  • Simple – No staining or sample preparation
  • Fast – Results in as little as 10 secs
  • Unique – cell volume based detection and aggregation correction
  • Reliable – highest reproducibility even in critical applications (PBMC, Cell- & Immunotherapy, stem cell research, biomanufacturing, …)
  • Modular – configure your CASY just the way you need it
  • Cell QC – viability, cell size distribution (0,7-120um)

Globally, thousands of users, industrial and academic, trust CASY, the legend in cell counting. Whether working with mammalian cells, yeast, bacteria or one of many other cell types, CASY users rely on the unmatched precision, reproducibility and accuracy of the instrument combined with easy and intuitive use.

Cell Counter CASY

Why CASY cell counter provides superior performance

CASY uses Electronic Current Exclusion (ECE) technology. During measurement, each particle, nuclei or cell passing through the defined pore generates an electronic signal. The intensity correlates directly with their size and conductivity.

Electronic Current Exclusion means that CASY uses a frequency of 1 MHz for detection of cells passing the pore and integrates the signal over time of passage. As a result, CASY detects precisely the volume of cells, independent of their shapes.

Viability: Viable and Dying/Dead cells are detected with different volumes. Viable cells, with a polarized membrane generate a high resistance signal correlating with the full volume of the cell. Dying or dead cells display a much lower resistance due to their depolarized or fully disrupted cell membrane.

Aggregation correction: CASY provides a large dynamic measuring range, which ranges from small debris to even large aggregates of cells. Aggregates are detected precisely by their total cell volume which allows calculation of the number of single cells they include.

Flexibility: CASY can be used for a large variety of sample types including Bacteria, Yeast, Algae and Protozoa, Platelets, PBMC, various Mammalian,  different StemCells and more. Additionally CASY can be customized to individual needs – please contact us for more details.

Reliability and Precision: Several thousands of cells detected in a single measurement in no time are the basis for CASY’s highest reproducibility and reliability. Even working with replicates and mean results are options of the new CASY software. Try yourself and compare with other counting methods.

We have successfully been using CASY for 10 years now. With CASY we are able to carry out reproducible cell culture experiments even when working with highly aggregated cells. CASY allows us to consider cell concentration and aggregation when seeding and harvesting cells, as both are measured by CASY. Measuring accurately cell number, the aggregation factor and the cell volume, gives us the opportunity to express analytical data as concentration per cell. Additionally and the molar amount of a substance within a cell can be calculated (used for example for metal uptake in µM).

Prof. Dr. Julia Bornhorst, Food Chemistry, University of Wuppertal

We have been using CASY for the fast and reliable determination of cell concentrations and cell diameters of our cell cultures for 20 years now. We are still impressed by the high reproducibility of the measurements and the simple, intuitive operation of the device. The associated software offers great options for managing and displaying the measurement results graphically.

Dr. Heike Schwarz, Leitung Abteilung Zellbiologie, DIARECT AG

We study the regulation of cancer cell growth by signaling and metabolism. CASY is the ideal system for us to precisely measure proliferation and cell size of a wide range of cell lines. In this context, the new software makes instrument operation as well as data visualization and organization easy and convenient.

Dr. Wilhelm Palm, Head of the Junior Research Group Cell Signaling and Metabolism, German Cancer Research Center

We use CASY cell counter for toxicological studies at a single animal level. The CASY cell counter proved to be an accurate and sensitive instrument for ecotoxicological applications allowing fast, simple and label-free measurements.

Prof. Dr. Konstantinos Grintzalis, School of Biotechnology, Dublin City University

Cytotoxicity Assays using CASY enable us to perform fast, simple and reliable assessment of anti-cancer drug regimens and the subsequent chemosensitivity of carcinoma cell lines. A major advantage of CASY is that debris and dead cells can be masked in the analysis by a simple cell line specific setup and only viable cells and their aggregates are considered. However, as a complete cell status is recorded, also dead cells and debris data are available at any time.

Dr. J. Weinreich, Experimentelle Onkologie, Universiätsklinikum Tübingen

Advantages of the CASY-Technology

  • Dye-free – no sample preparation
  • High resolution size distribution
  • Highly accurate direct volume measurement
  • Volume based aggregation correction
  • Sensitive detection of alteration in cell sizes
  • Low sample volume and short measuring time (from 10 sec)
  • High accuracy (+/- 2 %) and repeatability
  • Low running costs
  • From R&D to Manufacturing QC
  • Automatic electronic control of all critical parameters
  • GLP/GMP compliant
  • 21 CFR Part 11 (optional)

CASY Remote Access

The CASY control software provides several optional modules to extend its functionality.
There are modules to authorize agains your Microsoft Active Directory Server or to help you getting compliant with the CFR 21 Part 11 standard.

One module provides the ability to remotly access your measurements. You can view your CASY measurement results from another instance of the CASY software and/or with our CASY Remote Access App for iOS and Android.

How does it work?

The CASY Remote Access module additionally installs a webservice on the CASY control computer providing remote access to your measurements via network. In the CASY software dashboard you can simply define the webservice address and remotly read-only browse your measurements. View your measurements as single graph, as overlay or in a mean curve as you know it from your local work.

CASY Remote Access App for your tablet or smartphone
You can also download our CASY Remote Access App for iOS and Android.
We’ve installed a sample webservice reachable with the app. Just download, install and start. The sample server is added as default address. Simply login with user “x” and password “x” to test the app.

Get it on Google Play

Upcoming CASY events

19th Oct

Analytica 2020

Fair | Messe Munich | 9 am

Smart Solutions from Cell Culture and Counting to Real Time Cell Analysis and Live Cell Imaging are offered by OLS OMNI Life Science at Analytica 2020. Visit our booth 210 in hall A3 to get the latest news for your powerful cell analysis. Join us for a drink and meet the OLS team.

Read more ›

Consumables

Name Article Number Description Quote Order
CASYton 5651808 Isotonic measurement buffer for all CASY models. Politainer for easy filling of consumption quantities, 1x 10 L Quote Order now
CASYcups 5651794 Measuring vessels for all CASY models. For dilution of the samples to be measured with CASYton and performing the cell count. 1 pack = 1800 cups Quote Order now
CASYclean 5651787 Capillary and system cleaning agent for all CASY models. To be used for acute decontamination and routine cleaning. 1 x 500 mL Quote Order now
CASYblue 5651760 Solution for controlled killing of cell culture cells for accurate adjustment of the left cursor evaluation, 4 x 30 mL Quote Order now

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