Flow Cytometry Synthetic Cell Controls by Slingshot
Spend less time qualifying results, and more time getting results. Slingshot’s Flow Cytometry Synthetic Cell Controls make these goals achievable in your experiments. The revolutionary technology decreases cost, shortens development timelines and increases stability, impact and accessibility. This is a new paradigm for drug development, diagnostics and cell therapy – one without limitations.
Spend less time and resources developing cell reference materials and QC standards and more time:
- Advancing translational research
- Achieving unparalleled cell analysis and biomarker quantitation
- Streamlining QC processes for cell therapies to get them to patients faster
Slingshot’s synthetic cells imitate real cells’ characteristics indistinguishably
Overview
The most advanced and ideal cell control
Through the intersection of biochemistry, polymer chemistry and high-precision manufacturing, we have created FlowCytes® – synthetic cells that are indistinguishable from real cells. The Slingshot platform is the world’s first on demand, synthetic cell design platform to address the industry’s reliance on and limitations around biologically-derived cellular controls. This breakthrough technology creates synthetic cells that match the optical, fluorescence and biochemical features of any cell type – even rare disease types. The result is the ideal cell control, achieved without sacrificing performance or consistency.
FlowCytes® are shelf stable and can be custom printed on-demand, at scale, in real time. Slingshot’s technology decreases cost, shortens development timelines and increases accessibility to cell controls. Our cutting-edge technology platform can be used in a range of applications including:
- Assay development
- Laboratory diagnostics
- Adoptive cell therapy
- Drug development
- Cell analysis instrument performance
The breakthrough technology creates synthetic cells that match the optical, fluorescence and biochemical features of any cell type, even rare disease types. FlowCytes® – the backbone of our products – are a series of synthetic cells assembled in a 3D spherical matrix, physically resembling a cell. FlowCytes® are nearly indistinguishable between live cells when analyzed in a flow cytometer. This makes FlowCytes® the ideal cell controls to calibrate, standardize and ensure performance for instruments and assays.
Synthetic Cells for high-precision calibration in flow cytometry
Complete Customization
Slingshot scientists can partner with you to customize our products to your needs, on demand. Our technology is built on proprietary predictive modeling, uniquely designed microsystems, and a manufacturing platform that precisely creates off-the-shelf solutions for cell-like reagents that are stable and cost effective, in just hours. We can quickly scale to bioprint custom FlowCytes® with extreme precision and high throughput while meeting high ISO 9001 quality standards.
Current methods vs. Slingshot
In flow cytometry, controls have traditionally come from blood donations or solid-core plastic beads. Current blood controls cannot be manufactured without using technology to combine human and animal cells or sourcing primary cells from active donors. Only <1% of blood diseases have available controls.
| Biological Controls
⊘ High cost ⊘ Batch-to-batch variability ⊘ Cell line maintenance ⊘ Biohazardous shipping and handling ⊘ Poor stability |
Polystyrene solid-core beads
⊘ High non-specific binding ⊘ No mimicking of cell autofluorescence ⊘ Fundamentally different properties from cells, incl. RI and FSC vs SSC |
The innovative technology from Slingshot Biosciences is designed to help researchers get customizable cellular controls quickly, without sourcing primary cells or generating cell banks. Even the rarest of diseases can accurately be profiled with an off-of-the-shelf control product.
Advantages of Slingshot technology
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Instrument Calibration Controls
FlowCytes® synthetic white blood cells (WBC) are shelf stable synthetic cells that mimic the optical properties of human blood populations for unfixed lymphocytes, monocytes, and granulocytes. This product is intended as a forward and side scatter control for the identification and analysis of whole blood populations.
The synthetic mimics can be used to measure flow cytometry instrument performance or as an assay control for traceability and standardization.
Features:
- Easy to use and seamlessly fits into existing workflow. No special handling and preparation, unlike with biological controls
- Highly precise performance with minimal lot-to-lot variability
- Long shelf-life and stability at room temperature for convenient use in the field
- Safe, non-biohazardous product that travels anywhere
FlowCytes® Fixed WBC Scatter mimic
Price on request
25 tests / vial
FlowCytes® non-fixed WBC mimics
Price on request
25 tests / vial
ScatterBridge™ is a solution that enhances the way we approach instrument standardization across sites and instruments, offering newfound performance tracking and longitudinal evaluation.
ScatterBridge™
Price on request
25 tests / vial
